Sildenafil, the active ingredient in Viagra, improves blood flow. This property makes it useful in treating pulmonary hypertension (PH), a condition where blood pressure in the arteries leading to the lungs is abnormally high. PH strains the heart and can lead to serious complications. Sildenafil works by relaxing the blood vessels in the lungs, lowering blood pressure and improving blood flow. It’s specifically used for a type of PH called pulmonary arterial hypertension (PAH).
How Sildenafil Works in PAH
Sildenafil inhibits an enzyme called phosphodiesterase-5 (PDE5). This inhibition increases levels of cyclic guanosine monophosphate (cGMP), a molecule that relaxes smooth muscle in blood vessel walls. This relaxation widens blood vessels, reducing pressure and improving oxygen delivery to the body. While Viagra is primarily known for treating erectile dysfunction, its mechanism makes it effective for some types of PH.
Important Considerations
Sildenafil is a prescription medication. A doctor must diagnose PH and determine the appropriate dosage and treatment plan. It’s crucial to discuss any existing health conditions, allergies, and medications before starting treatment. Common side effects can include headache, flushing, and nasal congestion. Serious side effects are rare but should be reported to your doctor immediately. Always follow your doctor’s instructions regarding dosage and usage.
