These medications–sildenafil, vardenafil, and tadalafil–belong to a class of drugs called phosphodiesterase-5 (PDE5) inhibitors. They work by increasing blood flow to the penis. Specifically, they inhibit the PDE5 enzyme, which normally breaks down cyclic guanosine monophosphate (cGMP).
Increased cGMP levels relax the smooth muscles in the blood vessels of the penis, leading to vasodilation. This vasodilation allows more blood to flow into the penis, resulting in an erection. The effect is triggered by sexual stimulation; these drugs don’t cause erections without sexual stimulation.
While they share a similar mechanism, subtle differences exist in their duration of action and metabolism. Tadalafil, for example, generally lasts longer than sildenafil or vardenafil. This difference stems from variations in their half-life and how they are processed by the body.
It’s vital to consult a healthcare professional before using any of these medications. They can help determine the appropriate dosage and address potential interactions with other medications or underlying health conditions. Remember to discuss your medical history fully for safe and effective use.
