For persistent pulmonary hypertension of the newborn (PPHN), sildenafil’s initial intravenous dose is typically 0.5 to 1 mg/kg, administered over 10-15 minutes. This dose may be repeated every 4 to 6 hours based on clinical response and blood gas analysis.
Careful monitoring of blood pressure, heart rate, and oxygen saturation is paramount. Adjustments to the sildenafil dosage depend heavily on the infant’s response; increased doses are carefully titrated upward to achieve desired physiological effects, always under strict medical supervision. Remember that individual responses vary significantly.
Oral sildenafil can be considered as a maintenance therapy post-discharge, often starting at a lower dosage. The precise oral dose and schedule will be determined by a neonatologist based on the infant’s condition and response to prior treatment. Transitioning from intravenous to oral administration requires close observation.
Caution: Sildenafil is a potent medication with potential side effects. Hypotension, flushing, and changes in retinal blood flow should be monitored. Always follow your physician’s instructions and closely observe your child for any adverse reactions. Consulting with a medical professional is crucial before administering sildenafil or making any adjustments to the dosage.
