Actoplus Met, combining metformin and pioglitazone, can cause various side effects. Many are mild, but some require medical attention.
Gastrointestinal Issues: Expect nausea, vomiting, diarrhea, or abdominal pain. These usually lessen as your body adjusts. If symptoms persist or worsen, contact your doctor.
Weight Gain: Weight gain is a possibility with pioglitazone. Maintain a healthy diet and exercise regimen to mitigate this. Consult your doctor about weight management strategies.
Hypoglycemia (Low Blood Sugar): This is more likely if you also take insulin or other blood sugar-lowering medications. Symptoms include dizziness, sweating, and confusion. Carry glucose tablets to treat low blood sugar episodes.
Fluid Retention: Swelling in your ankles, legs, or feet can occur. This is often linked to pioglitazone. Notify your doctor if swelling is significant or concerning.
Liver Problems: Rarely, Actoplus Met can cause liver problems. Your doctor will likely monitor your liver function through blood tests.
Heart Failure: Pioglitazone may increase the risk of heart failure, especially in patients with pre-existing heart conditions. Discuss this risk with your doctor before starting treatment.
Bone Fractures: Some studies suggest a potential increased risk of bone fractures. Maintain a calcium-rich diet and consider weight-bearing exercise.
Bladder Cancer: A possible increased risk of bladder cancer has been linked to pioglitazone. Regular checkups are important.
Allergic Reactions: While uncommon, allergic reactions such as rash, itching, or hives can occur. Stop taking Actoplus Met immediately and seek medical help if you experience an allergic reaction.
This information is not exhaustive. Always consult your physician for complete information and personalized advice regarding side effects and management.


