Combining azithromycin and doxycycline increases your risk of side effects. Gastrointestinal issues are common, including nausea, vomiting, and diarrhea. These effects are usually mild and temporary, but severe cases warrant immediate medical attention.
Photosensitivity, or increased sun sensitivity, is another potential risk. This means you’re more likely to get sunburned. Protect your skin with sunscreen (SPF 30 or higher), wear protective clothing, and limit sun exposure, especially during peak hours.
Both medications can affect your liver. While rare, serious liver damage is possible. Report any signs of liver problems, such as jaundice (yellowing of skin or eyes), dark urine, or unusual fatigue, to your doctor immediately.
Interactions with other medications are possible. Always inform your doctor and pharmacist of all medications, supplements, and herbal remedies you are taking. This prevents potentially dangerous drug interactions.
Allergic reactions, though infrequent, can occur. Watch for signs like rash, hives, itching, swelling, or difficulty breathing. Seek immediate medical care if an allergic reaction develops.
Finally, remember to follow your doctor’s instructions precisely regarding dosage and duration of treatment. Improper use can worsen potential side effects.


