Grapefruit juice inhibits CYP3A4, an enzyme your liver uses to break down Viagra (sildenafil). This inhibition means less Viagra is metabolized, leading to higher levels of the drug in your bloodstream.
Increased Viagra Levels & Potential Risks
Elevated sildenafil concentrations can increase the risk of side effects. These can include headaches, flushing, nasal congestion, and, in rare cases, more serious cardiovascular issues. The increased blood levels may also prolong the duration of Viagra’s effects, potentially causing undesirable consequences.
Understanding the Interaction
CYP3A4 processes many medications. Grapefruit juice’s impact on CYP3A4 isn’t limited to Viagra; similar interactions occur with other drugs metabolized by this enzyme. Always inform your doctor about all medications and supplements you’re taking, including herbal remedies.
Recommendations
Avoid grapefruit juice and grapefruit products while taking Viagra. This precaution minimizes the risk of adverse reactions stemming from elevated sildenafil levels. Consult your doctor or pharmacist if you have questions or concerns regarding drug interactions.
Alternative Medications
If grapefruit is a dietary staple, discuss alternative erectile dysfunction treatments with your doctor. They can assess your individual needs and suggest medications not metabolized by CYP3A4 or that have less interaction with grapefruit.
