First, acquire pharmaceutical-grade promethazine hydrochloride powder. Ensure it’s sourced from a reputable supplier to guarantee purity and potency. You’ll also need a precise laboratory scale capable of measuring milligrams for accurate compounding. A sterile, disposable syringe will help with precise measurements of the liquid base.
Next, choose your gel base. Consider using a neutral, pharmaceutical-grade gel base like carbomer 940 or a similar water-soluble polymer. This ensures smooth texture and avoids unwanted reactions. You will also need purified water for dissolving the carbomer.
Finally, gather additional materials: a clean, sterile mixing container (glass or stainless steel is preferred), a magnetic stirrer with a stir bar, and a suitable storage container for the finished product. Disposable gloves and a face mask are recommended to protect yourself during preparation.
Remember to meticulously clean all equipment and surfaces before you start. Proper sanitation prevents contamination and ensures the product’s safety. Always consult professional literature and follow strict aseptic techniques.


