Propranolol XL 60 mg interacts with many medications. Always inform your doctor about all medications you are taking, including over-the-counter drugs, herbal remedies, and supplements. Failing to do so can lead to serious health consequences.
Interactions Requiring Caution:
- Verapamil and Diltiazem (calcium channel blockers): Combining these with propranolol significantly slows heart rate and can cause dangerously low blood pressure. Your doctor might need to adjust your dosages. Digoxin (heart medication): Propranolol can increase digoxin levels in your blood, potentially leading to toxicity. Regular monitoring of your digoxin levels is necessary. Insulin and Oral Hypoglycemics: Propranolol can mask the symptoms of low blood sugar (hypoglycemia). Closely monitor your blood sugar, especially if you are diabetic. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Combining propranolol with NSAIDs like ibuprofen or naproxen can reduce the effectiveness of propranolol and increase the risk of bleeding. Monoamine Oxidase Inhibitors (MAOIs): Concurrent use with MAOIs may significantly lower blood pressure.
Other Significant Interactions:
CYP2D6 inhibitors (e. g., fluoxetine, paroxetine): These can increase propranolol levels, potentially leading to increased side effects. CYP2D6 inducers (e. g., rifampin): These can decrease propranolol levels, reducing its effectiveness. Alcohol: Combining alcohol with propranolol can increase the risk of low blood pressure and dizziness. Avoid excessive alcohol consumption. Cimetidine (H2 blocker): Cimetidine can increase propranolol levels in the blood.
This list is not exhaustive. Always consult your physician or pharmacist before starting, stopping, or changing any medication while taking Propranolol XL 60 mg. They can assess your individual risk factors and provide tailored advice.
