Avoid alcohol completely. Mixing Promethazine with codeine and alcohol significantly increases the risk of respiratory depression and overdose.
Don’t combine this syrup with other sedatives, such as benzodiazepines (Xanax, Valium), sleeping pills, or strong antihistamines. This combination can cause extreme drowsiness and breathing problems.
MAO inhibitors are a strict no. These antidepressants interact dangerously with codeine, potentially leading to a serious condition called serotonin syndrome.
Be cautious with opioid pain relievers. Combining Promethazine with codeine with other opioids dramatically increases the risk of respiratory depression and overdose. Only use other pain medications as directed by your doctor.
Certain medications for nausea and vomiting can interact negatively. Check with your doctor or pharmacist before taking any antiemetics while using this syrup.
Always inform your doctor or pharmacist about all medications, supplements, and herbal remedies you are taking. This includes over-the-counter drugs. They can help assess potential interactions.
Grapefruit juice can interfere with the metabolism of codeine. Avoid consuming grapefruit juice while taking this medication.
