Valacyclovir can interact with several medications. Concurrent use with nephrotoxic drugs, like aminoglycosides or amphotericin B, increases the risk of kidney problems. Therefore, careful monitoring of kidney function is necessary when combining valacyclovir with these drugs. Closely monitor patients with impaired renal function.
Potential Interactions with Other Medications
Probenecid reduces valacyclovir excretion, potentially leading to higher valacyclovir levels. This necessitates dose adjustment or careful monitoring. Combining valacyclovir with immunosuppressants may increase the risk of opportunistic infections. Always inform your doctor about all medications you are taking, including over-the-counter drugs and herbal supplements.
Contraindications
Valacyclovir is contraindicated in patients with known hypersensitivity to valacyclovir, acyclovir, or any of its components. Pregnancy and breastfeeding require careful consideration. Individual risk-benefit assessment is crucial, involving discussions with your healthcare provider. Patients with severe renal impairment should avoid valacyclovir due to the risk of toxicity. Caution is advised in patients with a history of neurological disorders.
