Regularly monitor kidney function with blood tests measuring serum creatinine and estimated glomerular filtration rate (eGFR). eGFR provides a better indication of kidney function than creatinine alone. Target an eGFR above 60 mL/min/1.73m².
Urine tests, specifically looking for proteinuria (protein in the urine) and hematuria (blood in the urine), should be part of the assessment. Elevated levels suggest kidney damage. A 24-hour urine collection offers a more precise protein measurement.
Consider using cystatin C blood tests in addition to creatinine and eGFR. Cystatin C is less affected by age, muscle mass, or sex, offering a potentially more accurate assessment of kidney function, especially in individuals with impaired kidney function.
Ultrasound of the kidneys can help visualize the size and structure of the kidneys, detecting potential abnormalities. This is particularly useful if there is suspicion of kidney stones or other structural issues.
Adjust allopurinol dosage based on these test results. Lowering the dose or temporarily suspending treatment is often necessary to prevent further kidney damage. Closely monitor patient progress and repeat tests according to physician guidance.
