Both prednisone and methotrexate cause side effects, but they differ significantly. Prednisone, a corticosteroid, frequently leads to weight gain, increased appetite, fluid retention, and mood changes like irritability or anxiety. These effects are often dose-dependent, meaning higher doses increase the likelihood and severity. Long-term use can also result in osteoporosis and increased risk of infections.
Methotrexate, a disease-modifying antirheumatic drug (DMARD), presents a different profile. Common side effects include nausea, mouth sores, and fatigue. Liver function abnormalities are a possibility, requiring regular monitoring. Methotrexate can also suppress the immune system, increasing vulnerability to infections. Hair thinning is another potential side effect.
Specific recommendations regarding managing side effects should always come from your doctor. They will weigh the benefits against the risks and tailor treatment based on your individual health status and response.
Key Differences Summarized:
Prednisone: Weight gain, fluid retention, mood changes, osteoporosis risk (long-term).
Methotrexate: Nausea, mouth sores, fatigue, liver function monitoring needed, immune suppression.
Always discuss any concerns about side effects with your healthcare provider. They can help you manage these symptoms and determine the best course of treatment for you.
