Veterinarians sometimes prescribe Prednisone and Rimadyl together to manage canine pain and inflammation, particularly in cases of severe osteoarthritis or post-surgical recovery. This combination offers potential benefits by leveraging the anti-inflammatory properties of both drugs.
Prednisone, a corticosteroid, powerfully reduces inflammation, but long-term use carries significant risks, including increased thirst and urination, weight gain, and immune system suppression. Rimadyl (carprofen), a non-steroidal anti-inflammatory drug (NSAID), provides pain relief and reduces inflammation with fewer side effects than Prednisone, although gastrointestinal upset remains a possibility. Combining them allows for a lower Prednisone dose, potentially minimizing steroid-related side effects while maintaining adequate pain control.
However, combining these drugs increases the risk of side effects. The combined use necessitates careful monitoring for gastrointestinal problems like ulcers and vomiting, as well as signs of liver or kidney damage. Regular blood work is crucial to detect these complications early.
| Enhanced pain and inflammation control | Increased risk of gastrointestinal ulcers |
| Reduced Prednisone dosage, minimizing steroid side effects | Potential for liver and kidney damage |
| Synergistic effect for managing severe conditions | Requires close veterinary monitoring and regular blood tests |
Always discuss the potential benefits and risks with your veterinarian before starting this combination therapy. They will consider your dog’s overall health, age, and specific condition to determine the appropriateness and optimal dosage of both medications. Closely follow their instructions and report any concerning symptoms immediately.


