Consult your doctor about the timing of your flu vaccine. If you’re on a high dose of prednisone (20mg/day or more for two weeks or longer), delaying vaccination until your dose is reduced or discontinued might be advisable. This allows for a stronger immune response.
Timing and Dose Adjustment
Lower prednisone doses generally allow for a better vaccine response. Discuss with your physician the possibility of temporarily reducing your prednisone dosage before vaccination, if medically safe. This temporary reduction should always be carefully managed under your doctor’s supervision to avoid compromising your health.
Live Attenuated Vaccines
Avoid live attenuated influenza vaccines. These are generally unsuitable for patients on immunosuppressants like prednisone, as they carry a higher risk of complications. Inactivated influenza vaccines are the preferred option.
Vaccine Type
Opt for the high-dose influenza vaccine specifically formulated for seniors. These vaccines contain a higher antigen concentration, potentially leading to a better immune response even with immunosuppression. Your doctor can determine the most appropriate vaccine for your specific situation.
Monitoring and Follow-up
Schedule a follow-up appointment with your physician after vaccination to discuss any potential side effects and assess the immune response. Regular monitoring can help ensure the vaccine’s effectiveness and identify any issues early on.
Alternative Vaccination Schedules
Your physician may suggest an alternative vaccination schedule, particularly if your prednisone regimen is complex or unpredictable. This might involve multiple doses spaced strategically throughout the year to maximize protection.


